Furthermore, the more effective facilitation of the motor output during simultaneous ES and IS may reflect some convergence of pathways on the same interneuronal populations involved in the regulation of locomotion.
Thus, inactivation of a single node can be buffered by the use of alternative pathways to the same end product.
In order to construct a complete mevalonate pathway, the upper semi-pathway of the same bacterium, Streptococcus pneumoniae, was recruited.
On the other hand, the positions and sizes of compartments might differ between pathways of the same organism.
To address this issue, we have analyzed the levels and biological activities of IFN-α/IFN-γ in alternative regeneration pathways of the same species.
In addition, the best pathways of a certain substrate in Query 5 and not found in the best pathways of the same substrate in Query 2 have similar enzyme functions but dissimilar enzyme sequences.
For instance, the best pathways of a certain substrate in Query 2 and not found in the best pathways of the same substrate in Query 1 have similar enzymes but use different cofactors or less specific substrates.
Another particularity is that while the positions of elements common to different organisms are conserved within a pathway, their positions might differ between different pathways of the same organism.
These parallel pathways of the same sign may increase the system's robustness [ 54], but also resistance, for example, when cancer cells do not respond to (single) drugs because multiple pathways may still transduce an (aberrant) signal [ 55].
To estimate a p-value for significance of this pathway, we iteratively compute similar scores 10 times on randomly generated pathways of the same size as that of pathway P. The frequency of scores that are larger than Sp is used as the significance p-value of pathway P to describe its dysregulation in one specific brain region.
Figure 11b shows the equivalent molecular pathway model of the same pathway.
