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Hematopoietic-specific beta 1 tubulin participates in a pathway of platelet biogenesis dependent on the transcription factor NF-E2. Blood.
Methods Lotrafiban, a selective, nonpeptide antagonist of the human platelet fibrinogen receptor (glycoprotein [GP] IIb/IIIa [αIIb/β3 integrin]), blocks the binding of fibrinogen to the GP IIb/IIIa receptor, which is the final common pathway of platelet aggregation.
The pathway of platelet aggregation comprised nineteen target proteins [19].
Glycoprotein (GP) IIb/IIIa receptor antagonists, which interrupt the final common pathway of platelet activation and aggregation, have been shown to have clear clinical benefit as acute therapy.
METHODS: Lotrafiban, a selective, nonpeptide antagonist of the human platelet fibrinogen receptor (glycoprotein [GP] IIb/IIIa [alphaIIb/beta3 integrin]), blocks the binding of fibrinogen to the GP IIb/IIIa receptor, which is the final common pathway of platelet aggregation.
This suggests that polyphenol preparations can directly block the ADP-dependent pathway of platelet activation.
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The transport pathway of platelet-, blood cell-, and endothelial cell-derived as well as tubular epithelial cell-derived EMVs into the circulation and urine, respectively, appears to be straightforward.
A role for Rab27b in NF-E2-dependent pathways of platelet formation.
ACN supplementation has the potential to reduce the risk of thrombosis in overweight/obese population by targeting specific pathways of platelet activation/aggregation and endothelial dysfunction associated leucocyte migration.
Major pathways of platelet activation and pharmaceutical action are illustrated in Figure 1.
Antiplatelet therapy with NSAIDs and thienopyridines leads to an irreversible blockade of important enzymatic pathways of platelet activation.
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