Focusing on a specific pathway or a group of interrelated genes that are involved in fundamental tumor biology has also proven useful.
Especially for the elucidation of local network structures, knowledge of interrelated pathways can be of crucial importance.
This is a highly competitive arena due to the complexity of interrelated pathways contributing to inflammatory arthritis pathogenesis [ 66].
Furthermore, these IPA networks highlight the web of interrelated pathways that are differentially regulated in discs undergoing degenerative changes; not only may changes in expression of a single gene have wide downstream consequences but these figures hint that the existence of a single key mediator of disc degeneration is unlikely.
Consistent with these reports are our findings in asthmatics that ambient coarse PM is associated with increased serum triglycerides, decreased HRV, and increased circulating granulocytes (eosinophils), suggesting a complex network of interrelated pathways at work with respect to the health effects of PM exposure.
Liver regeneration after partial hepatectomy (PH) is a process of compensatory hyperplasia which involves all cell types within the remaining liver lobes and depends on the multitude of interrelated regulatory pathways that directly or indirectly control successful restoration of hepatic mass [1] [3].
One carbon metabolism is a network of interrelated biochemical pathways that donate and regenerate one-carbon units, including the methyl group (reviewed [ 19, 20]).
Several studies have shown that deregulation of STAT3, Akt, and ERK signaling is implicated in tumorigenesis [ 34- 39], suggesting that aberrant activity of a network of interrelated signaling pathways, rather than a single deregulated route, contributes to carcinogenesis.
Molecular biological investigations have confirmed that the transformed phenotype of HGG is highly complex and is the result of the dysfunction of a variety of interrelated regulatory pathways [ 10].
A total of 143 and 262 differentially expressed genes exemplify the early and late hemocyte response of the Vibrio-challenged mussels, respectively, with AMP trends confirmed by qPCR and clear modulation of interrelated signalling pathways.
