Sentence examples for pathway of elimination from inspiring English sources

Finally, a significant amount of cisplatin is eliminated in urine [ 8] and this pathway of elimination is dependent on renal output and hydration.

The initial activation is mediated by hepatic cytochrome P-450 enzymes and is the major pathway of elimination of the parent drug.

In mice orally administered 10 or 200 mg/kg of radiolabeled benzene, urinary excretion was the predominant pathway of elimination at the low dose (McMahon & Birnbaum, 1991).

The metabolism of bosentan is dependent on the activity of CYP2C9 and 3A4 isoenzymes, and excretion of the metabolites via the bile constitutes the major pathway of elimination.

The main pathway of elimination of nicotine from the foetal circulation occurs by re-diffusion across the placenta into the maternal circulation [ 8].

Secondly, the pathway of elimination for the OPG molecule is unknown, but a reduced renal excretion of OPG has been shown to explain part of the increased levels in type 1 diabetic patients (4).

These agents were considered because of the known differences in their primary pathways of elimination.

Apixaban and rivaroxaban also share similar pathways of elimination, including metabolism, mainly by cytochrome P450 3as (CYP3A4), as well as biliary and renal elimination, and have relatively similar terminal half‐lives (apixaban ∼12 hours; rivaroxaban ∼10 hours).

Extensive work has been conducted on natural (e.g. 17β-oestradiol) and synthetic oestrogens (e.g. 17α-ethinyloestradiol from the contraceptive pill) and their interactions in the vertebrate body, including their tissue distributions, mechanisms of action and pathways of elimination [ 5- 7].

Indeed, fibrates suppress bile acid synthesis, the major pathway of cholesterol elimination from the body [ 8, 9].

Phase II conjugation by glucuronidation is another major pathway of liver elimination of endogenous and exogenous compounds, and in D this molecular function was significantly overrepresented.