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C3b can initiate the alternative pathway of complement activation.
Among these, C3, CFI, and C4BPα were included in the pathway of complement cascades (P < 0.05).
Fish serum causes hemolysis of heterologous red blood cells, which is due to activation of alternative pathway of complement system.
C3 glomerulonephritis (GN) is a proliferative GN resulting from glomerular deposition of complement factors due to dysregulation of the alternative pathway of complement.
The sixth complement protein (C6) is an essential component of the membrane attack complex (MAC); the end product of the lytic pathway of complement activation.
Complement factor H (CFH), the main cofactor for CFI, regulates the alternative pathway of complement activation by acting in the breakdown of C3b to iC3b.
Dysregulation of the alternative pathway of complement may occur as a result of mutations or functional inhibition of complement-regulating proteins.
A novel therapeutic reagent TT30 was designed to be effective in diseases of the alternative pathway of complement such as paroxysmal nocturnal hemoglobinuria and other diseases.
However, the pathway of complement activation was not defined.
The alternate pathway of complement activation is potentially important than the classical pathway.
These functions included biotransformation, steroid and tryptophan metabolism, extrinsic blood coagulation, and the lectin pathway of complement cascades.
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