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Figure 1 Biosynthetic pathway of catecholamine neurotransmitters.
Tyrosine hydroxylase is an enzyme in the pathway of catecholamine synthesis; it converts tyrosine into DOPA and can be used to localize neurons producing catecholamines.
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Although DA concentration is the direct cause of such diseases, since the biosynthetic pathway of major catecholamine neurotransmitters has been well-understood (Figure 1), the concentration measurements of these individual neurotransmitters (L-Tyrosine, L-DOPA and DA) could provide meaningful insights on the failure mechanisms along the pathway.
A preliminary glimpse of this type of analysis was achieved before structural genomics efforts with the glycolytic pathway and efforts are underway for many other pathways, including that of catecholamine metabolism.
These findings suggest that lower recruitment of subcortical resources and impaired inhibition of cortical resources may be mediated by abnormal functional connectivity of catecholamine (dopamine, norepinephrine and serotonin) pathways in cocaine abusers.
In contrast to the previous studies performed on plants over-expressing tyrosine decarboxylase [ 7], which controls an important step of catecholamine synthesis, the goal of our work was to stimulate an alternative signalling pathway by introducing human dopamine receptor.
Therapeutic intervention: fluid infusion or increase dosage of catecholamine.
The need of catecholamine and their doses are also recorded.
Glucocorticoids are known stimulators of catecholamine biosynthesis.
However, visceral fat exhibits higher catecholamine-induced lipolysis through increased expression of catecholamine receptors.
The consequent hypotension often necessitates high doses of catecholamine administration.
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