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Since acetoacetyl-CoA reductase requires NADPH, the pathway modification that causes excess NADPH yields higher PHB production [102].
Furthermore, the amount of P incorporated into carbon instead of the specific surface area of the P-doped carbon xerogel is found to play a critical role in the ORR activity enhancement and the ORR pathway modification.
Although significant progress has been made in understanding the downstream signaling cascade of this pathway, little is known regarding Wnt/β-catenin pathway modification of the cellular apoptosis.
Overall, it may be concluded that biomass sources with reduced recalcitrance resulting from lignin pathway modification are a valuable resource for producing economical biofuels.
The utility of the model to explore biological implications of Wnt pathway modification and the role of the OCY in bone remodeling was demonstrated.
Other approaches are certainly possible, and will largely be informed by the ever-increasing list of combinatorial pathway modification strategies [ 81].
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For metabolic engineering purposes, the CRISPR-based tools have been applied to single and multiplex pathway modifications and transcriptional regulations.
Combining those deletions with other mevalonate pathway modifications increased production of bisabolene from 40 mg/L to 800 mg/L in shake-flask cultures.
The applied constructional design facilitated versatile pathway modifications and the generation of various expression constructs, which were evaluated for the production of CFA, COR and its derivatives.
An equivalent circuit modeling-based approach indicates that these features are mostly originated from paracellular pathway modifications due to host parasite interactions.
To try to correlate subjective photophobic symptoms with visual pathway modifications (from the retinal image to the visual cortex) after refractive surgery by exploring brain activation on photic stimulation.
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