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This altered cellular metabolic pathway meets the survival and proliferation needs for tumor progression.
Glycolysis and citric acid cycle are the main pathway for organisms to produce energy; the pentose phosphate pathway meets the need of all organisms for a source of NADPH to use in reductive biosynthesis; polysaccharide can store energy for organisms growth and development.
The mismatch repair (MMR) pathway meets these criteria: the gene encoding the DNA MMR protein (msh6, PF3D7_0505500) is a functional partner of pfcrt in CQS but not CQR parasites and this pathway can be induced by small molecules such as methyl methanesulfonate (MMS) [ 60].
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Multiple genes encoding members of the LIF/gp130 signaling pathway met the definition of cartilage-selective genes.
A recent attempt to engineer S. cerevisiae strains carrying a bacterial D-GalA catabolic pathway met with considerable challenges in expressing functional enzymes [ 16, 30].
It is also worth noting that while several genes in the UPR pathway met the strict criteria for sleep repressed genes in both tissues, a larger set met the criteria in only one.
Neural signals in the form of spike train from the left and right auditory pathways meet at some coincidence counter after traveling along the left and right delay lines and trigger the counter, which is in fact a physiological cross-correlation calculator.
Together, these two pathways meet at SecYEGDF.
Twenty different pathways met the predetermined significance level of a negative log of the p value ≥ 4 (Fig. 4).
In a cell, the substrates of a pathway are usually the products of another pathway, and there are junctions where pathways meet or cross (Karp and Mavrovouniotis, 1994).
Gene lists (Entrez IDs) for pathways meeting our criteria were downloaded and compiled into a master list, while maintaining their sources (Additional file 2: Table S 4).
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CEO of Professional Science Editing for Scientists @ prosciediting.com