Sentence examples for pathway lower from inspiring English sources

28 With respect to the functional pathway, lower limb muscle weakness favors OA progression and vice versa.

Intriguingly, we observed that patients with higher IR-A/IR-B mRNA ratio generally showed upregulated oxidative phosphorylation pathway, lower epithelial-mesenchymal transition (EMT) gene expression signatures in NSCLC and exhibited longer survival under standard of care in LUSC.

Oxidative stress affects the intrinsically linked FA and 1-C cycle metabolism: FAs decrease in chain length and unsaturation (particularly omega-3 polyunsaturated FAs), and lipid peroxidation products increase; the 1-C cycle shifts from the methylation to transsulfuration pathway (lower folate and higher homocysteine and antioxidant glutathione).

In asymmetric divisions controlled by the Wnt/β-catenin asymmetry pathway, lower POP-1 resulting from Wnt signal transduction in one daughter is associated with activation of target genes whereas greater POP-1 in the other daughter is associated with repression of target genes (Sawa and Korswagen 2013).

However, it appears that inhibiting the SAPK/JNK pathway lowers the degree of inflammatory response seen as cytokine expression in the tissue both at mRNA and protein levels.

For example, data mining on gene expression profiling reveals an association between hyperactivity in the PI3K pathway, lowered ER levels, and resistance to endocrine therapy.

3, 13, 14 Besides impacting on the structural and functional components of the neurovascular unit, deposition of Aβ within the perivascular drainage pathway lowers the motive force of Aβ clearance, thereby contributing to increased parenchymal Aβ deposition.

A compound named butyrolactone, a product for γ-hydroxybutyric acid (GHB), also known as 4-hydroxybutanoic acid, a naturally occurring substance found in the CNS, as well as in wine, beef, and citrus fruits, increases the levels of the insulin-degrading enzyme (IDE), suppresses autophagy via the mTOR pathway, lowers Aβ levels and prevents AD-like cognitive deficits in APP/PS1 mice [ 71].

This implies that there may be cross-talk between DNA repair and heat-shock resistance such that in stationary phase the function of the DNA repair pathway lowers the cells' ability to resist heat shock, or in the mutants the cells adapt to become more heat-shock resistant in response to an accumulation of DNA damage in stationary phase cells.

At the metaphase to anaphase transition in mitosis, the anaphase promoting complex (APC/C) becomes activated and geminin is targeted for polyubiquitination and degradation via the 26S proteosome pathway, lowering levels to the point where the protein no longer interferes with assembly of pre-RCs during the following G1 phase [ 17].

Multiple physiological and cognitive factors such as damaged nociceptive pathways, lower pain thresholds and mood contribute to the prevalence of pain in the elderly population.