Even if the rate of regeneration is faster in wnt5b/pipetail mutant that in wild type fish [20], the difference suggests that another pathway is involved in the repression of fgf20a expression.
To illustrate, the abscisic acid (ABA) pathway is involved in the repression of lateral root development and adaption to environmental stresses [ 53, 54].
Cholesterol accumulation in membranes of the endoplasmatic reticulum (ER) results in a down-regulation of the SREBP pathway and subsequently in the repression of 3-hydroxy-3-methyl-glutaryl-CoA-reductase (Hmgcr), the rate limiting enzyme of the de novo cholesterol biosynthesis [ 2].
HIF plays a central role in the transcriptional response to hypoxia, so the role of the HIF pathway in the hypoxic repression of Dicer levels was examined.
Activation of AKT leads to a significant reduction in E-cadherin expression and nuclear localization of Snail, suggesting a role for the PI3K/AKT signaling pathway in the transient repression of E-cadherin.
The Piwi-interacting RNA (piRNA) pathway plays an essential role in the repression of transposons in the germline.
Our data further suggest that the binding of pSmad1 to the BRE locus is potentially compromised in the presence of Pou3f1, which results in the repression of BMP signaling pathway activity.
This growth suppression was observed even if the Kennedy pathway was inactivated by the repression of PCT1 encoding CTP phosphocholine cytidylyltransferase, suggesting that PC synthesized in the mitochondria is distributed to other organelles without going through the salvage pathway.
At loci of stress response and developmental regulators such as ste11, Atf1 and Set1 appear to act in parallel pathways that contribute to the repression of ste11 as loss of both atf1 and set1 resulted in significant derepression of ste11.
These two genes function in maintaining the repression of the major target of the vernalization pathway, the floral repressor FLC.
