Sentence examples for pathway in the first from inspiring English sources

It is striking that the most significantly upregulated pathway in the first degree relatives is Insulin Signaling, whereas it is the single most downregulated pathway in people with type 2 diabetes.

The contamination pathway in the first known case of an outbreak associated with imported mangoes is particularly paradoxical.

Moreover, a bifurcation analysis identified translocation of pSTAT1 dimers to the nucleus as a critical step for regulating the dynamics of type I IFN pathway in the first steps, which may be important in defining the response to IFN-beta therapy.

An explanation was presented by Covert et al. [ 9] who proposed that the activation of NF-κB by TRIF-dependent pathway is a result of a secondary response to TNFα, which is induced by IRF3 (this latter activated by the TLR4/TRIF-mediated pathway in the first response to LPS) and signals through the TNFα receptor (TNFR)/RIP1 pathway to activate NF-κB.

While the immune system was the most up-regulated pathway in the first acorn developmental stage (S1), followed by metabolism of other aminoacids and secondary metabolites, in middle stages of development (S2 to S5) up-regulation of carbohydrate, nucleotide, glycan biosynthesis and energy metabolism was observed.

Dr. Lipan is now teaching the mathematical modeling of cell signaling pathway in the second semester of the IQS course.

Indeed, IPA analysis identified that 163 canonical pathways were significantly associated with those genes (data not shown) with a large proportion of immune-related pathways in the first top 30 (Figure 2).

Therefore, we introduced two alternative reaction pathways: In the first variant, we assume that the MCC APC complex dissociate into MCC and APC (reaction Eq. (7a)), subsequently allowing the MCC to disassemble into its parts according to reaction Eq. (4) (Dissociation variant).

42 This would certainly help explain why bacteria and other highly optimized organisms activate latent pathways in the first place.

The upregulation of TP53 signaling pathways in the first 24 h following ibuprofen treatment has been also shown by a previous study [ 133].

For example, based on the 5598 permuted pathways in the first simulation process, we obtained the genes' correlation values of the pseudo pathways in 108 expression profiles (shortened as Table II).