Here we discuss the recent advances in understanding the role of different Wnt signaling pathways in the assembly of the postsynaptic structures by focusing our attention to synapses in the central and peripheral system in different model organisms.
Importantly, we also verified that the cupD system encodes an effective chaperone-usher pathway involved in the assembly of fimbrial structures, since CupD1 fimbriae could be specifically detected on the bacterial cell surface only upon cupD gene activation via RcsB.
Proteins of the canonical wingless signalling pathway participate in the assembly of the NMJ, with crucial components being the wingless co-receptor, arrow, Dishevelled and GSK3ß.
Taken together, these studies place septins at the top of a signaling pathway involved in the assembly of the diffusion barrier in the ER-membrane at the bud neck, and Bud6 and sphingolipids at the bottom.
Overall, it seems possible that three activation pathways result in the assembly of specific ESCRT-III filaments, each with different subunit requirements, length and dynamics.
For example, MetaCyc lacked pathways involved in the assembly of the major surface glycoconjugates of Leishmania, including the biosynthesis of glycosylphosphatidylinositols (GPIs) and related glycolipids, and the assembly of complex phosphoglycans on the cell surface and secreted proteins and glycolipids [ 26].
In the wing, malfunction of any one of the elements in this pathway disturbs the assembly of F-actin prehairs and leads to the aberrant generation of multiple hairs on each cell (Fig. 5A), which are usually interpreted as a defect in PCP or its output.
Fusion in the secretory pathway depends on the assembly of four SNARE domains stemming from the two different organelles that are about to fuse.
Pathway engineering is the assembly of a new or improved biochemical pathway, using genes from one or more organisms.
A schematic view of the steps involved in the assembly of this pathway is shown in Figure 1.
