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A previous study by our group documented the involvement of the extrinsic pathway in the activation of programmed cell death in PD.
This suggests the involvement of the PI3K/AKT signaling pathway in the activation of EBV in GFP-Akata cells inside CNE-2 cells.
However, the potential role of the c-Cbl-dependent MAPK/ERK pathway in the activation of T cells has not been identified.
Taken together with our studies in IRF9-/ mice, the results of these experiments demonstrate a critical role for the IFN-I pathway in the activation of B cells and subsequent autoantibody production in response to TLR agonists.
Although ROCK does not appear to phosphorylate FAK on Ser732, as suggested previously, we cannot exclude involvement of Rho/ROCK pathway in the activation of the signaling circuit MEK/ERK/FAK/ERK.
To elucidate a possible participation of the CWI pathway in the activation of the gene expression in these mutants, we proceeded to generate pmt2Δ slt2Δ, pmt2Δ rlm1Δ, ssd1Δ slt2Δ and ssd1Δ rlm1Δ double mutants.
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Unlike with CTLA-4, the TcR employs multiple pathways in the activation of PKB/AKT [36].
The critical roles of NFκB- and STAT-mediated signaling pathways in the activation of many ISGs and genes coding for various pro-inflammatory mediators have been well characterized [54], [55].
In the present study, we could not exclude the involvement of other signaling pathways in the activation of MCs.
This prompted the present focus on these two transmembrane signalling pathways in the activation of HPCs in canine liver diseases.
We however used different methods to link the pathways in the activation of AP-1 in TMZ-resistant GBM cells.
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