We were also interested in discovering pathways that are candidates for contributing to the observed insulin resistance.
EGFR signaling has been implicated in tamoxifenresistance in preclinical models [ 36, 37], which could have significant implications for treatment, and lends further credence for EGFR pathway overexpression contributing to worse clinical outcomes in ER+ preM breast cancers.
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Since the distribution of D is not available, two typical PEM statistics were proposed for detecting the pathway effect contributing to the disease.
In summary, the bootstrap-based methods are preferred for identification of the pathway effect contributing to disease.
The proposed bootstrap-based PEM are valid and powerful for detecting the specific pathway effect contributing to disease, thus potentially providing new insight into the underlying mechanisms and ways to study the disease effects of specific pathways more comprehensively.
Bootstrap-based pathway effect measures are valid and powerful for identifying the specific pathway contributing to disease, providing potential new insight into underlying mechanisms and more comprehensive ways to study the disease effects of specific pathways.
The complementary mechanisms of action of an angiotensin receptor blocker, calcium channel blocker, and diuretic result in each agent targeting a separate pathway and provide coverage for multiple different pathways contributing to hypertension [ 14, 25, 35].
Notch signaling, a critical pathway for tissue development, contributes to tumorigenesis in many tissues; however, the roles of Notch signaling in Intrahepatic Cholangiocarcinoma (ICC) remains unclear.
The redesign of the pathway for elective surgery contributed to a sustained reduction in CRs and an increased number of performed operations.
Bootstrap-based PEM are valid and powerful for identifying the specific pathway contributing to disease, thus potentially providing new insight into the underlying mechanisms and more comprehensive ways to study the disease effects of specific pathways.
