Sentence examples for pathway ends in from inspiring English sources

Since the 5AR pathway ends in DHT binding to the AR to initiate prostate growth, we analyzed AR gene expression as well.

Therefore, it is reasonable to think that all the data relating glycaemic and HbA1c with HF development risk [ 5- 8] could be explained based on the AGE-RAGE axis, since the glucose-fructosamine-HbA1c pathway ends in AGE [ 11] as pentosidine or carboxymethyl-lysine and these molecules can mediate myocardial remodelling towards cardiac dysfunction.

Granule neurons project their axons to the stratum lucidum of the CA3 area (mossy fibre pathway), ending in synaptic boutons that progressively increase in size during maturation (Fig. 5C and D).

In general, synthesized or recycled proteins will be transported predominantly to central regions of the cellular plasma membrane, with less transport pathways ending in lamellipodia.

This pathway ends with C299 located in hydrogen-bonding distance to the amine head-group of the adt-ligand.

The Golgi apparatus is also involved in an internal secretory pathway that ends in the vacuolar compartment.

The targeting of Aβ42 to rafts may have important biological consequences as many of the proteins that are targeted to rafts avoid the classic endocytic trafficking pathway that ends in the lysosomes [ 22, 57].

One of the main downstream effectors of the epidermal growth factor receptor (EGFR) is ras GTPase, an integral molecule of the mitogen activated protein kinase (MAPK) pathway which ends in the phosphorylation of extracellular signal regulated kinase (ERK).

Often, overexpressed transporters enter a cellular degradation pathway ending up in vacuoles.

Regardless of the mechanism, the apoptotic program triggered by TNFRSF1A in endothelial cells involves a positive regulatory feedback between the intrinsic and extrinsic apoptotic pathways, which ends in the upregulation of caspase-8, further contributing to the apoptosis of endothelial cells.

The total direct costs for each treatment outcome or pathway that ended in a termination node ran from a low of $33 (cost of an OTC product and travel, pharmacist pathway) to a high of $562 (psychologist accessed through a health practitioner pathway).