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These database tools which visualize pathways are limited in features such as pathway editing, query pathways, etc.
> Besides these pathway drawing and pathway editing tools, a huge effort is also observed to develop various pathway analysis tools by different database developers.
PathText distinguishes itself from other pathway editing tools by providing a seamless combination of advanced TM technologies, including deep syntactic analysis of individual sentences (MEDIE), named entity recognition and disambiguation of acronyms (KLEIO), and real time co-occurrence searches (FACTA).
The current workflow for pathway curation has two phases working in a cyclical manner, as shown in Figure 1: pathway editing using biological pathway editors (CellDesigner) and community-driven pathway enrichment and knowledge sharing.
However, our biologist centric approach to this problem, combined with a lack of flexible pathway editing tools, the scale our diagrams and the range of biological systems we have attempted to map, have all played their part in determining the design and implementation of the mEPN scheme.
In the second group of applications, those known as web-based or desktop applications, Cytoscape (29) is a tool that represents biological pathways and covers a wide set of features such as pathway editing, exporting of pathway representation to different formats, etc.
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The pathways showing the relationships among the genes on the list were drawn by selecting all molecules on the pathway edit window.
However, we have tested whether the successfully validating outputs are also validated after pathway edits performed with CyKEGGParser or by the user in Cytoscape environment.
These pathways are a community resource hosted on the Plants portal at WikiPathways (http://plants.wikipathways.org), an open and central curation platform, where registered users can make their own contributions to plant science by creating new networks of known and/or published pathways or editing the existing ones.
(A ) All the squid proteins present in the KEGG 'Synaptic vesicle cycle' pathway are edited, and most are heavily edited.
On average, 74% and 22% of the identifiable proteins in each pathway are edited or heavily edited, respectively.
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