Furthermore, we identified transforming growth factor-β (TGF-β) signaling as a key pathway downstream of TFEB inactivation.
Activated ERK not only mediates RAS pathway downstream signaling that regulates various cellular process but can also mediate feedback regulation of RAS pathway32,33,34,35,47,48.
Interestingly, FUS knockdown affected neither the c-NHEJ factors KU70 and DNA-PK nor ATM substrates, such as 53BP113, consistent with our data suggesting poly(ADP-ribose) mediated a-NHEJ as the DDR pathway downstream of FUS.
SRF, serum response factor, functions as a regulator of c-fos and cell cycle progression as well as MAPK pathway downstream signaling, and it is a well-studied transcription factor in cancerous tissues65,66.
We provide evidence that MYB acts in a conserved pathway downstream of Notch signaling and multicilin, a protein related to the S-phase regulator geminin, and upstream of FOXJ1.
These data indicated that Ginkgetin may inhibit Wnt signaling pathway downstream of β-catenin destruction.
Constitutive activation of the JAK/STAT pathway downstream of Unpaired partially rescues the disk growth defects in Ipk2 mutants.
Studies are currently underway to further elucidate the signal transduction pathway downstream from these receptors and to establish their role in regulating tumor-induced angiogenesis.
Our results indicate that OsMADS45 overexpression potentiates its effects on the OsGI-Hd1-Hd3a flowering signaling pathway downstream of OsGI and upstream of the Hd1 and Hd3a genes.
Our laboratory has identified the nuclear hormone receptor, LXR-ß, as a protein that binds to activated ALK-1, is phosphorylated by ALK-1 and modulates ALK-1 signaling,establishing a novel signaling pathway downstream of ALK-1.
One key signaling pathway downstream of GPCRs is mediated via phosphoinositide 3-kinase γ (PI3Kγ).
