The leading edge genes in this pathway differentiating only the ovarian survival datasets include five members of the chemokine ligand (CXCL) family, including one chemokine receptor, as well as four interleukin (IL) members coding proteins embedded in the cell membrane of immune system cells, including T and natural killer (NK) cells.
Although the role of ROS and antioxidants in maintaining symbiosis in vivo has not yet been determined, it will be interesting to see if these pathways differentiate between insects that can establish a long term association with symbionts and those that cannot.
Thus, although the DACS Network shares many features with other previously published networks, we believe the inherent computability conferred upon it by the BEL Framework and the ability to evaluate biological mechanisms by RCR (as opposed to direct mapping of differentially expressed genes onto pathways) differentiates the DACS Network from previously existing resources.
The specific aims of this study were: i) to identify candidate genes differentially expressed in perennial ryegrass during cold acclimation, ii) to identify molecular pathways differentiated between genotypes adapted to cold and warm climates, and iii) to identify the transcriptional mechanisms underlying carbon allocation towards fructan biosynthesis during cold acclimation.
We propose a hierarchical Bayesian model for analyzing gene expression data to identify pathways differentiating between two biological states (e.g., cancer vs. non-cancer and mutant vs. normal).
During the body's early development, stem cells in the skin develop along three different pathways, differentiating into hair follicles, into sebaceous glands for secreting fat to lubricate and waterproof the skin, and into the epidermis itself.
The highly significant pathways differentiating sepsis and SIRS included response to wounding, defense response, and the immune or inflammatory response.
Adolescents seeking sex reassignment represent a variety of developmental pathways differentiated by the timing of onset of gender dysphoria, psychopathology and developmental difficulties.
The Gene Ontology (GO) classes and KEGG pathways differentiating the conditions studied were computed using parametric gene set enrichment analysis [ 33, 80].
The differential disease resistance response of nec1 plants might result from the activation of specific resistance pathways differentiating between various types of pathogens.
