Exact(30)
In contrast, the average pathway connectivity (number of pathways a pathway is connected to) decreases from prokarya to eukarya: bacteria species have denser NIPs than both archaea and eukarya species as shown by the total adjacency, average node degree, and connectedness (or density).
We argue that as scientists continue to estimate the in-stream turnover of terrestrially-derived carbon in fluvial carbon budgets, the assumption of pathway connectivity between carbon sources to the stream should be justified.
The author used a multi-criteria approach operating at the street level, and during the model's first step, each pathway received a walkability index score based on the following five evaluation criteria: pathway connectivity, access to public transportation, land-use mix, housing density and the greenness level.
A relative pathway connectivity score was used to rank upregulated pro-cardiac transcripts according to the degree of connectivity via hubs to highways of cardiogenic specification (Equation 3).
In a second test we compared the pathway connectivity of hubs in the stable component network with that of metabolites having no hub property in the stable component network.
Similar(30)
Our method involves the development of ODE models corresponding to different signalling pathway connectivities, all of which can explain current wild type experimental data equally well.
It is well known, however, that models of comparable complexity corresponding to different pathway connectivities may fit experimental data equally well, leaving the researcher with the dilemma of which model is correct [ 6].
Unfortunately the pathway score is weighted by classic Hypergeometric enrichment analysis (HGA) and the authors do not discuss how results differ based solely on intra-pathway connectivity.
In such cases, a-priori localization data is not available for any enzyme in a certain pathway, and hence pathway enrichment-based methods are bound to fail, requiring a network-based view of pathways connectivity.
This is unlike other common approaches for building pathway or connectivity maps where connections are often represented without regard for tissue or disease contexts.
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