Exact(46)
Regulation of DNA repair pathway choice is crucial to avoid genomic instability.
With these inhibitors, we examined repair pathway choice at DSBs generated in G2 following radiation exposure.
We discuss what factors determine the sub pathway choice including etiology of the DSB, chromatin structure at the break site, processing of the DSBs and the mechanisms regulating the sub-pathway choice.
BRCA1-A contributes to checkpoint regulation, repair pathway choice, and HR repair efficiency through molecular mechanisms that remain largely obscure.
We discuss possible ramifications of this model in cellular DSB management and pathway choice, and analyze its implications in radiation carcinogenesis and the design of novel therapeutic approaches.
Furthermore, they collectively help to explain how MRN regulates DNA repair pathway choice with implications for improving the design and analysis of cancer clinical trials that employ DNA damaging agents or target the DNA damage response.
Similar(14)
This doesn't much matter, because the original story, which was first published in Playboy in 1970 and runs about 10 pages, is merely a humble scaffolding for Mr. Kelly's mazelike narrative, with its sharp and snaking turns, its periodic dead ends and various pathway choices.
This issue describes the pathway choices that are particularly representative of women, as will be described in the following section.
Oxygen is a bioactive molecule which impacts strongly on intracellular signalling, mitochondrial function, and metabolic pathway choices.
The structure of the node processing system is algorithmic but uniquely embodies preferred or weighted pathway choices, based on physiological needs, sociological needs, associative memory encapsulation and many other features.
The canyon widens again and offers several pathway choices, from full sun at the middle of the canyon to full shade on the eastern or right side.
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