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In the fourth step we determine the development grade of each sub-technology, identify possible correlations and interdependencies in a pathway, check whether the pathways go in line with the acquirer's vision and outline the trajectories of technological development.
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At the same time, the metabolism pathway check-up would inform on the level of energetic consumption linked to cancer aggressiveness.
This paradoxical situation suggests that there must be additional mechanisms that keep the apoptotic pathway in check prior to NF-κB-mediated induction of anti-apoptotic genes.
Now, it is possible to compare all reactants to the pathway components, check for missing reaction participants and eventually add those to the KGML.
Therefore we analysed a recently published comprehensive model of the HOG pathway to check its predictive properties given part of the experimental data used to build the model [ 26, 27].
37, 38 By searching and browsing pathway trees, check the excitatory neural signaling through 5-HTR 4 and serotonin and leave the other options as their defaults, as shown in Figure 2a.
Caspase-8 can cleave both RIPK1 and RIPK3 and is needed to keep the necroptotic pathway in check (Vandenabeele et al., 2010; Kaiser et al., 2011; Oberst et al., 2011).
STAT1 signal pathway was checked to investigate the signal mechanism.
The NMD machinery is part of a larger set of RNA surveillance pathways that check the integrity of mRNAs before rendering them available for translation in the cytoplasm.
These results suggest that the inhibition from iPNs usually keeps the aversive pathways under check.
Interferon- γ is an important antiproliferative cytokine that is involved in multiple pathways to check the tumour progression (Brandacher et al, 2006).
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