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We confirmed that this pathway can be abrogated by inhibition of various signaling molecules including PKCs.
Activation of autophagy by an mTOR-independent pathway can be achieved using calpeptin, which inhibits the autophagy inhibitors calpain proteases55.
The NF-κB pathway can be activated by translation inhibition directly by changing stoichiometry of activating and inhibiting subunits54.
With such approach, the optimal conversion pathway can be determined based on different optimisation objectives.
For Roberts and his ilk, the final stage of the pathway can be harder than the rest of the journey put together.
Hence, a renal/hepatobiliary excretion pathway can be assumed.
Right now ROS1 pathway can be inhibited with crizotinib.
And now that pathway can be manipulated--or exploited.
Another way a metabolic pathway can be controlled is by feedback inhibition.
Hence, the PI3K/Akt pathway can be an attractive target for cancer therapy.
By analysis of the dominant reaction rates, the reaction pathway can be identified.
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