Sentence examples for pathway blockage from inspiring English sources
"pathway blockage" is correct and usable in written English
You can use it to describe a physical impediment that is blocking the progress of someone or something. For example: "The pathway blockage caused by the fallen tree made it impossible for the hikers to cross the bridge."
White petals fail to produce the stress responsive flavonoid intermediates in the anthocyanin biosynthetic pathway (ABP), suggesting an early pathway blockage.
Consistently, we observed that sorafenib activates the energy sensor AMPK [ 27], further inducing mTOR pathway blockage.
Overexpression of other tyrosine kinase receptors, like c-met, may bypass the HER2 signalling pathway blockage (Minuti et al, 2012).
Indeed, the upregulation of angiopoietins may be a major mechanism underlying the inadequate therapeutic effects of VEGF-A pathway blockage [ 9, 22].
In this regard, emerging evidence indicates that upregulation of angiopoietins may be a major mechanism underlying the inadequate therapeutic effects of VEGF-A pathway blockage [ 9, 22].
In particular, we tested two approaches inducing an upstream (NAC) or a downstream (JNK1/2 and p38 inhibitors) CM signaling pathway blockage.
Metabolomic assay of pool levels are better for detecting the presence of pathways and detecting the site of pathway blockages, but changes in pathway fluxes may not result in increases or decreases of pool levels.
This has been interpreted as a direct on-target effect of VEGF-pathway blockage.
These changes were shown to be brought about via the induction of the EFNB2 and Akt cell signalling pathways, in that the expression of NNMT was shown to activate these pathways, whereas blockage of the pathways using (1) siRNA gene silencing of EFNB2 and (2) inhibition of Akt phosphorylation using LY294002 abolished the effects of NNMT-V5 expression.
The knowledge that all four growth factors were required for disc growth raised the question of whether the growth factors were activating their canonical signaling pathways, and if blockage of those pathways could inhibit disc formation.
Moreover, the detection of phosphorylated PDK-1, AKT, or mTOR through the simplicity and reproducibility of IHC staining might provide the treatment regimen that simultaneously inhibit multiple kinases within the same signalling pathway, ensure the blockage of the pathway, which ultimately reverse the malignant phenotypes.
