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For others who wish to use and explore these data we have constructed an online database which enables rapid evaluation on a single gene or pathway basis.
High-throughput transcriptome discovery across multiple pathways enhanced by proteomic approaches reduces the significance of outlier data points, such as increased IRF-3 gene expression by HIV-1 in a single donor, which may be difficult to interpret on an individual pathway basis by a single method.
Both approaches work on the pathway by pathway basis.
Our small sample size prevents confident detection of patterns on a biological pathway basis (for example, combinations of various HRR and BER factors generating a more complex genetic signature).
To investigate the extent of population differentiation on a pathway basis, we constructed pathway frequency maps (see Methods) that combine polymorphism frequencies of each CNV-gene pair in each population and are visualized using a heatmap (see Figure 3 and Additional file 3: Figure S3).
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Names that are created by the expert author and curator on an as-needed per-pathway basis may not be recognizable or interpretable by other biologists.
Due to factors such as the aforementioned possible constraint imposed by low activated-molecule counts during early signal amplification events in the phototransduction response, the influence of system topology on molecular evolution should be considered on a per-pathway basis, in order to properly evaluate other system-derived constraints.
In section Results, we discuss the application of ReTrace in reconstructing biosynthesis pathways on basis of genomic evidence.
Each query protein sequence from M. oryzae was assigned probable pathways on the basis of pathways obtained from KEGG database for their homologous protein sequences in other species (See Additional file 1: Schematic representation of pathway prediction in M. oryzae ).
Solid lines depict strong support for a pathway (on the basis of the metagenomic data sequence abundance), whereas dashed lines indicate little to no support for a pathway.
This pathway provided the basis for a model proposing that the SGI premotor cells that project to brainstem gaze centers and discharge before saccades also activate neighboring GABAergic neurons that suppress saccade-induced visual activity in SL.
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CEO of Professional Science Editing for Scientists @ prosciediting.com