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Optimization of the synthetic pathway allowed us to identify two general methods depending on the particular nucleoside analogs.
Additionally, availability of genotyping data for a large number of tag SNPs across the BER pathway allowed us to comprehensively explore the hypothesis that BER genetic variation might modify pesticide-associated prostate cancer risk.
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Comparative analysis of metabolic pathways allowed us to identify unpredicted metabolic pathways of cattle using the automated procedures and to annotate functions to cattle genes in a metabolism-centered way.
Targeted analysis of specific biological pathways allowed us to compare genes from many different gene families simultaneously.
Our results, combined with previously reported signaling pathways, allowed us to illustrate a signaling network, by which miR-17 functions.
Integrating behavioural and genetic data with information from interception records and historical trade pathways allowed us to begin to reconstruct the likely introduction history of L. humile into Australia.
Our results also clearly reveal the major efferent fiber routes leaving the STG, and the delineation of these pathways allowed us to identify the points where they were disrupted by the MTL lesion.
The positions of predicted and matched HIV-1 targeted proteins along KEGG pathways allowed us to assess the extent of matching between computational and experimental prediction based on cell-compartment identity.
The knowledge of the different pathways allows us to design the interactions between amino acids that guide the protein to fold through the least preferred pathway.
Values associated with genes/proteins are mapped into Higher Order Variables (HOV) based on broad biological classifications including KEGG modules, COG letters, Enzyme Class numbers and MetaCyc pathways, allowing us to rapidly detect and evaluate system-wide changes in expression levels.
Mouse models with specific genetic modifications in the components of these pathways allow us to probe the ramifications of well-defined alterations with an eye toward parsing endophenotypes of pathological conditions and behaviors.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com