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For example, 13C-labeled positions inside a molecule offer a hint about paths of molecular conversions.
The molecular paths associated with the phenotype differences of S. cerevisiae under conditions of different oxygen provisions revealed paths of molecular interactions that could potentially mediate information transfer between processes that respond to the particular oxygen availabilities.
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We introduce a method EMPath (Enriched Molecular Path detection) for detection of molecular paths of physical interactions in an integrated network of protein-protein interactions, signal transduction maps and metabolic pathways by applying a modified version of the color coding algorithm [7].
Figure 9 displays an example of the path for molecular pair 17 [pentamidine (CID 4735) and 2-imino-3- 1H-indol-3-yl propanoic 2-imino-3- 1H-indol-3-yl propanoic 2-imino-3- 1H-indol-3-yl propanoic 2-imino-3- 1H-indol-3-yl propanoic 2-imino-3- 1H-indol-3-yl propanoic 2-imino-3- 1H-indol-3-yl propanoic 2-imino-3- 1H-indol-3-yl propanoic
Hence, analysis of their lineage, paths of differentiation, and molecular determinants may provide important insights into general mechanisms of self-renewal.
Tunnels are access paths connecting the interior of molecular systems with the surrounding environment.
Additionally, we allow wild type definitions on atoms and bonds of molecular paths for fuzzy algorithms on structural match.
Since our primary aim as related to T1D was to study tissue-specific changes of molecular paths during the early disease pathogenesis, the appropriate study design should include young pre-diabetic mice with selected controls.
Another interesting observation is that the up-/down-regulation of molecular paths in early insulitis in our study matches particularly well with the data from the FoxA2 deficient mouse (Figures S6 S7 and reference [20]).
Recently, several graph theoretical methods for detection of molecular paths in an interaction network context have been developed.
The detection of molecular paths was performed in an integrated genome-scale metabolic and protein-protein interaction network.
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