Sentence examples for paths of differentiation from inspiring English sources

Therefore the Npm1/Sox2 interaction was investigated during different paths of differentiation.

Hence, analysis of their lineage, paths of differentiation, and molecular determinants may provide important insights into general mechanisms of self-renewal.

PCA of all these microarray data uncovered three major paths of differentiation from undifferentiated ES cells in 3D transcript profile space (Fig.  1B; Supplementary Video S1).

Alternative paths of differentiation can be investigated with the use of statistical models with higher order dependencies (Chaudhuri et al., 2007; Thiesson et al., 1998), which currently do not provide an efficient and exact method for the estimation of relevant dependencies.

Notch mainly exerts its functions through lateral inhibition, a process by which a cell - having acquired a certain phenotype - inhibits neighboring cells to take the same path of differentiation.

(1) The histological heterogeneity of osteosarcoma may indicate an origin of mesenchymal stem cells, along their path of differentiation to the osteoblastic lineage.

We observe that each of the chemotherapy curable malignancies arises in a cell type that normally has a complex developmental path of differentiation into its mature progeny.

PRC regulation is particularly important in ESCs, where polycomb repress so-called bivalent genes which are either activated or repressed depending on the further path of differentiation [ 21].

It is assumed that this cell is selected randomly and that it has started the path of differentiation in the sense that such a cell will never again be selected to reproduce in the stem cell pool.

While the absence of brain tumor may be in line with our observation that genotoxicity in Nde1 mutant neural progenitors occurred when they become fate restricted along the path of differentiation towards post-mitotic neurons, it is still interesting to learn whether cortical neurons can truly forgive the genomic lesions they inherit from their precursors.

"For Current, the focus on teens was a strategic decision and one of our paths to differentiation.