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The results include 57 pathology terms exhibiting expression of the cDNA sequences.
For example, we derived clinical pathology terms from OPPTS guidelines and collected clinical pathology laboratories and organ pathology terms from various public resources, including the National Toxicology Program's Pathology Code Tables (2007).
Specifically, we employ a computational comparative gene expression analysis to map the cDNA sequences to anatomical information, developmental timelines, cells and pathology terms.
For organ pathology terms, each target organ has a set of regions, zones, and cell types that characterize the site of toxicity.
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Severe, progressive skeletal pathology, termed dysostosis multiplex, is a prominent clinical feature of MPS VII.
Temporal lobe epilepsy, a common disease, is frequently the consequence of a characteristic hippocampal pathology termed hippocampal sclerosis, which may also affect the amygdala.
These poor outcomes are mainly attributable to a distinct pathology termed post-CA syndrome [ 7].
The mapping of pathology term expression annotation with our orthologous gene sets resulted in 57 terms having gene counts.
Urwin and colleagues reported that 36% of patients presenting a subtype of FTLD with FUS pathology, termed atypical FTLD-U, had hallucinations or delusions [ 31].
A key hypothesis of the Sanitation Hygiene Infant Nutrition Efficacy (SHINE) trial is that a subclinical intestinal pathology, termed environmental enteric dysfunction (EED), underlies child stunting [ 1].
To date, the only subtype of cases reported to have ubiquitin-positive but tau-, TDP-43 and FUS-negative pathology, termed FTLD-UPS, is the result of charged multivesicular body protein 2B gene (CHMP2B) mutation.
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