Exact(2)
In individuals with hippocampal pathology, template selection is critical (Avants et al., 2010).
Patients with biopsies were reviewed by at least one of the members of the dermatopathology faculty (MTT, VGP, CAT, MSM, DI, WLW, and JLC) and included all reported histologic parameters in a melanoma pathology template, specifically including Clark level (CL), Breslow thickness (BT), mitotic rate (MR), and ulceration (U).
Similar(58)
These results are in line with those of recent clinical studies comparing similar strategies, albeit not against a gold standard of pathology or template biopsy.
This differential efficiency could be attributed to a myriad of different properties ranging from stability of the aggregated αS, differential ability to template pathology, immunogenicity, or some combination of these factors.
To further investigate the hypothesis that αS pathology can self-template and spread from the periphery into the CNS via peripheral nerves, PFSPs were injected in the hind leg muscle (either biceps femoris or gastrocnemius) in M83+/+, M83+/− or M20+/− αS mice [ 161].
Although studies using cerebral injection of PFSPs or brain extracts are suggestive of induction and spread of αS induction pathology by protein conformational templating, there are many important issues to consider that make it likely the experimental procedures potentiate this process and that several other mechanisms are involved (Fig. 3).
AS and OE designed the template for the pathology report in electronic form.
In this project, cMDX-templates of the pathology report were implemented in the local HIS and the medical staff received on-the-job-training.
Such "system-autonomous" development of Lewy pathology is related to the shared "structural template" of thin unmyelinated hyperbranching axon structures that facilitates LB pathology (Figs. 4, 5), which provides the basis for the concept of "focal LB disease".
This apparent spread of αS inclusion pathology has been attributed to amyloid-like conformational templating.
Creating standard templates in electronic medical records for pathology and surgery reports may be another method that can improve both quality and consistency of data collected and reported.
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