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FENSAM is based on pathology response rate, clinical indicators, and pathologic markers (Mittendorf et al, 2011; Yi et al, 2011) and is reliable and easy to use.
All these effects were taken as evidence of a pathology response.
Moreover, some studies have demonstrated a correlation between early changes in F-FDG primary tumour uptake after one or two courses of chemotherapy and the extent of pathology response at completion of treatment, at the tumour level (Schwarz-Dose et al, 2009; Wang et al, 2012), as well as in axillary lymph nodes (Straver et al, 2010; Rousseau et al, 2011).
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On a single case level, a compensation claim can function as a feedback system, eg, a general practitioner and practicing specialist missed a breast cancer diagnosis due to an inappropriate procedure of pathology responses.
The advantage of this sequence is that neoadjuvant trials could generate results based on pathology responses much faster than any other approach and could provide critically needed guidance for the design of adjuvant trials.
Because numbers of patients in each dose group were small and there is no a priori reason to believe that pathology responses are dose-related, analyses have been performed combining the dose groups (although for information tables and figures present data separately).
Surgical pathology revealed a complete pathologic response.
Importantly however, there was a hint that there may be cognitive benefits as well as reduced amyloid pathology in response to immunization.
In patients with triple-negative breast cancer (TNBC), pathology complete response (pCR) to neoadjuvant chemotherapy (NAC) is associated with improved prognosis.
Both the diagnostic pathology and response assessment were reviewed by the EOI pathology sub-committee.
In terms of vascular pathology the response of most interest is that of changes in cell number.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com