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In addition to the known markers of hepatic pathology, random forest modeling uncovered putative novel candidate genes whose expression may predict the development of hepatic steatosis.
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The Braak model of PD staging hinges on the notion that Lewy pathology is not random: vulnerable sites in the brain are affected in a predictable topographic sequence.
Second, as is the nature of collaborative projects, each study had a different level of pathology review and random misclassification cannot be ruled out, which would bias results towards the null in histologic-specific analyses suggesting that our results may be attenuated.
In this study the association between the severity and genotypes was not found compared with a study from Zimbabwe that used ultrasonography to characterize the extent of urinary tract pathology of infected children, and random genetic markers to examine the relationship between genetic diversity of S. haematobium and clinical outcome.
The clustering of these pathologies is not considered a random event: rather, they probably have common pathogenic mechanisms.
Alzheimer's disease (AD) is a degenerative disorder where the distribution of pathology throughout the brain is not random but follows a predictive pattern used for pathological staging.
In phase 1 of the IOTA study, 10% of the patients were selected at random for central review of pathology.
The global sample at baseline was divided into two random sub-samples, stratifying by pathology and severity group (n1 = 533 and n2 = 547).
For each gene, a mixed linear model (MLM) including the factor pathology group G (tumour or NAT), the random factor patient P, and the factor exon E was fitted (gene MLM; equation 1).
This study used existing clinical pathology data rather than a population-based random sample or community-wide screening as attempted in other studies summarised in the Additional file 1: Table S1.
Such a practice of random sampling can result in sampling errors, missed pathology, unnecessary work for pathology departments, and increase in costs of investigations.
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