Literature concerning PRP use in rotator cuff pathology is mainly oriented towards intra-operative use of this biological strategy.
The pathology sample was oriented and fixed transversely to cork discs with OCT and then snap frozen in iso-pentane cooled on dry ice.
In the Pathology laboratory, the specimens had been routinely oriented and embedded in paraffin wax with standard sections at three levels.
The breast specimen, once excised, was oriented in a Plexiglass™ box using the clips and sutures to maintain orientation with the surgeon and pathology.
On the basis of these results, a new skin pathology-oriented PIQOR™ microarray was designed.
Moreover, a Cox regression analysis performed on the pathology-oriented variables (Table S11) revealed that cluster 2 significantly and independently correlated with risk for poor prognosis, even after correction for confounding factors (P = 0.022).
Because AIDA is a pathology-oriented inventory, the central quality standard lies in the diagnostic or predictive validity, i.e. the potential to differentiate healthy from impaired development.
This has now expanded and fused with more classical differentiation paths and, quite recently, with more translational and pathology-oriented trends.
In the absence of convenient model systems, pathology-oriented systems biology approaches are often limited to the collection of large data sets, without the possibility of performing multiple perturbations that are required to understand the dynamic properties of the system.
However, the quality of a theory-based and pathology-oriented inventory, such as AIDA, hinges on the criterion validity, i.e. the potential to clearly differentiate healthy from impaired development.
