In addition to established methods for bacterial load determinations, new technologies are emerging that allow us to specifically evaluate effects of vaccines on the pathology of the disease process and the expression by the host of cell mediated immunity.
"There is a need to develop better animal models, to recapitulate and predict effects of agents on the molecular pathology of the disease process, and also to develop better imaging and biomarker technologies to assess, as early and precisely as possible, drug effects in clinical studies," he says.
17 Increasing evidences suggest that there are decreased vascular density and cerebral microvascular pathology in the process of aging and neurodegeneration and cerebrovascular dysfunction, and CSVD precedes or accompanies cognitive dysfunction and neurodegeneration.
Digital pathology refers to the process of digitization of tissue slides.
There are many anatomical changes in retinal pigment epithelium (RPE), Bruch's membrane, and choriocapillaris in response to chronic oxidative stress, hypoxia, and disturbed autophagy and these are estimated to be crucial components in the pathology of neovascular processes in AMD.
Representative paraffin-embedded tissue blocks of 95 lung cancer patients were taken from the archive of the Department of Pathology of the University Medical Center in Utrecht and routinely processed into a tissue microarray (TMA).
Dysregulation of IL-6 production is implicated in the pathology of several disease processes, 7– 9 and increased IL-6 levels have been associated with rheumatoid arthritis, systemic-onset juvenile chronic arthritis, osteoporosis and psoriasis.
The interpretation of test results often depends on human factors (e.g. radiology, pathology, etc) or on the process of testing (e.g. clinical examination).
In particular, the abundance alterations of collagens are closely related to the injury and repairing of tissues, fibrosis pathology and the physiologic process of tissue regeneration.
The density of pE-Aβ aggregates steadily increased in entorhinal cortex and additional neocortical structures were subsequently affected by pE-Aβ pathology during the aging process of Tg2576 mice.
