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In the Braak et al. (2003) staging scheme of Parkinson's disease pathology, nigral and magnocellular basal forebrain pathology occur simultaneously.
Brain tissue changes characterizing AD including amyloid β plaques and neurofibrillary pathology occur more often in patients with cerebrovascular disease than in healthy elderly people.
In addition, it has been shown that only when three transgenes, specifically, PS1, APPsw and tau P301L, are inserted into a mouse model, can Aβ, synaptic dysfunction and tangle pathology occur (Oddo et al., 2003).
Furthermore, early signs of synaptic dysfunction and degeneration have been demonstrated in Ppt1 deficient neurons in vitro (16) and synaptic and axonal pathology occur early on in disease progression in the congenital form of NCL (17) and synaptic involvement in a mouse model of INCL was also recently demonstrated (18).
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"Some of the [non-epidemiological] work done looking at bones of horses that have suffered fractures has indicated that it is clearly where pre-catastrophic fracture change, adaptation or pathology occurs – though no one really knows which one of those it is – that are the most common types of catastrophic fracture we see in a racehorse," said Parkin.
When this pathology occurs in patients with an active growth cartilage, bone surgery is contraindicated.
As seen, a variety of pathology occurs within the sublingual and submandibular spaces, as well as the surrounding regions.
The synaptic pathology occurs prior to neuronal degeneration and may therefore prove useful as a target for future therapeutic design.
Venous valve incompetence role as the primary pathology occurring in patients with chronic venous diseases (CVD) has long been exaggerated.
Therefore, our findings also suggested that treatment response of depression might be associated with local or distant damage from Aβ pathology occurred in these brain regions.
When a pathology occurred in >50% cell or area in maximum investigated slides, it scored severe,followed by >25% for moderate, and <25% for mild.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com