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The induction of a similar response by the bacterial lipid TDM implies that this is a pathogen-driven response, which results in a metabolic shift that induces the pathology necessary for the pathogen to complete its life cycle.
Thus we conclude that ESAT-6 has a leukocidin function, which may facilitate bacterial avoidance of the antimicrobial action of the neutrophil while contributing to the maintenance of inflammation and necrotic pathology necessary for granuloma formation and TB transmission.
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Integration of plant breeding and plant pathology is necessary to underpin crop improvement for food and other plant-based production.
Measures of population healthcare education and restriction of attention in the ED exclusively for urgent pathology are necessary.
A greater understanding of multiple sclerosis pathology is necessary to allow more effective disease management and therapeutic intervention, yielding improved patient outcomes.
As the reversibility of renal function may be dependent on the pathogenesis of renal disease, correct renal pathology is necessary for successful treatment.
Importantly, a behavioural assay correlating with CC pathology is necessary to quantify deficits during acute demyelination and to subsequently test strategies to promote remyelination.
Biomarkers that efficiently distinguish between frontotemporal lobar degeneration (FTLD) with TDP43 (TAR DNA-binding protein 43) or tau pathology are necessary for the development of disease-modifying treatments and to identify patients for inclusion/exclusion from clinical trials.
Long-term treatment in this pathology is necessary in order to minimize the risks of relapse and recurrence and also to allow optimal quality of life as well as social and personal functioning [ 1, 2].
Statements by the IARC, along with other USA agencies (CalEPA, RoC/NTP) on the carcinogenicity of formaldehyde for humans renders its substitution in Pathology Departments necessary since the annual use of formalin may exceed 3,500 liters for a medium-large laboratory.
In particular, pre-clinical models resembling human pathologies are necessary.
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