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If, on the other hand, the hypothesis is that a pharmacological provision of glutamine may be beneficial, the target group should be patients with a high mortality risk with a pathology likely to respond to effects associated with providing a surplus of glutamine.
The most likely co-morbid confounder is cerebrovascular disease, so that we looked at the potential impact of pathological confounding by repeating the analysis to exclude patients in whom examination of the brain showed evidence of a stroke since these individuals have vascular pathology likely to cause functional decline.
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In addition to the prioritized list of PMIDs, competitors are also asked to provide additional annotations of interest to maintain the CTD with the interacting entities (small molecules and gene products) and the pathologies likely to reflect the toxicity of the chemical compound; see (5) for more detailed information about all tasks of BioCreative 2012 and CTD.
This was a multi-centre predominantly prospective study funded in part by the National Health and Medical Research Council (NHMRC) and Clinical Genomics Technologies Pty Ltd CGTto to estimate the sensitivity and specificity of a test detecting methylated BCAT1 and/or IKZF1 DNA in blood from people with neoplasia or non-neoplastic pathologies likely to be encountered in the colon and rectum.
Diffuse AS-PLA oligomeric pathology is likely to be a precursor to recognized neuritic and perikaryal pathology.
... The overall professional and educational value of the Fetal and Neonatal Pathology is likely to be an important contributory factor in persuading young pathologists to choose fetal and neonatal pathology as their life-long career opportunity.
This tissue-restricted pathology is likely to explain why the phenotype described here is compatible with a normal lifespan and has not been reported before.
The underlying cellular pathology is likely to be equally as complex.
Gaining new knowledge about why aged cells and tissues are more vulnerable to pathology is likely to catalyse radical new insights and opportunities to intervene.
The transition from physiology to pathology is likely to involve first a sequence of molecular changes, eventually followed by cellular changes and structural damage.
Ultimately, any anatomic focus of significant hypothalamic pathology is likely to have multiple effects given the integrative role of this structure [ 31].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com