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We conclude that rather than by a 'simplistic' gain- or loss-of-function mechanism, SCA1 pathology is triggered by complex alterations of its normal interactome, some of which even exert a protective role against disease.
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Ventricular arrhythmias, contractile dysfunction, and Ca2+ overload is triggered as part of that pathology.
"An emotion is triggered.
Accordingly, exercise-based pharmacological interventions for many muscle wasting diseases and also for pathologies that are triggered by a sedentary lifestyle remain scarce.
These pathologies were already known to be triggered by multiple genetic and environmental factors.
The pathology of polyQ diseases may also be triggered by the formation of abnormal protein complexes.
In this sense, a previous study suggests that TDP-43 aggregation may be triggered by Aβ, independently of tau pathology [ 50].
The presence of an underlying pituitary or adrenal pathology can lead to an acute adrenal failure, which can be triggered by sepsis.
Land mines are triggered.
It was triggering me.
Detailed information on life-time exposure to physical activity might further elucidate the matter: if strenuous physical activity early in life shows a stronger association with later knee replacement it would indicate that the level of joint pathology is the key factor triggering surgery.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com