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The social pathology hypothesis is, therefore, supported infanticide as social pathological behavior is infrequent in animal species due to natural selection [2].
In conclusion, our novel fly models have extended the non-cell autonomous pathology hypothesis as well as the developmental effect hypothesis to multiple polyQ diseases.
In conclusion, our fly models expressing mutant hHtt and hAtx1 in glial cells or glial lineage stem/progenitor cells have extended the non-cell autonomous pathology hypothesis as well as the developmental effect hypothesis to multiple polyQ diseases.
That type P tumors are also found in MMTV-infected mice was expected because Wnt1 is activated in 75% of mammary carcinomas arising in C3H/HeJ mice [ 52], and this observation supports the validity of the pathway pathology hypothesis.
Additionally, the "social pathology" hypothesis for infanticide has been proposed to explain certain cases of infanticide as an apparently maladaptive social behavior or an epiphenomenon associated with aggression generally, which conveys no apparent benefits to committing infanticide [Curtin, 1977; Curtin & Dolhinow, 1978; Hrdy, 1979; Sussman et al., 1995].
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The multi-dimensional machine learning methodology presented is well suited for investigating multiple associations between pathologies, generating hypotheses about potential interrelationships.
Application of statistics to data sets from toxicologic pathology studies involves hypothesis testing, model fitting, and reduction of dimensionality.
Association of IL10 with increasing pathology supports the hypothesis that IL10 may play a role in reducing collateral tissue damage [48].
The discovery of a compound that promotes inclusion formation while reducing toxicity and cellular pathology supports this hypothesis (Bodner et al., 2006).
The notion that mimicry between a self and a microbial peptide antigen can trigger or aggravate autoimmune pathology remains a popular hypothesis in autoimmunity research.
Assuming validity of these findings, the above trend was observed in healthy state and a causal link to inception of pathology may be hypothesized (hypothesis 1).
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