These variables mainly depend on the methods of PRP preparation and conservation, the type of activators, the type of pathology treated, the dose used, and the mode and times of administration.
Treatment with P. tuber regium improved these observed pathologies in a dose dependent manner (Fig. 6c, d and e).
The simplest explanation for differences in the severity of phenotype and pathology is a dose-threshold effect.
As discussed above, pro-inflammatory factors likely play a dual role during TB, and may mediate protection when produced in low doses or induce pathology when secreted at high doses.
We observed a significant association between endometrial pathology and both cumulated dose and total duration.
z axis-restricted CT guided by this region could detect pathology while reducing radiation dose.
Pathology changes at higher dose 300 mg/kg indicated that hepatocytes necrosis, fibrogenesis in hepatic lobules, and cholecystectasis with partial leakage of gallbladder epithelial cells were the basis for hepatic function damage.
Batf3 −/− mice developed exacerbated and unresolved cutaneous pathology following a low dose of intradermal L. major infection in the ear pinnae.
Carcinogenicity testing today normally includes 2-year studies in rats and mice of both sexes, following widely accepted procedures for husbandry; selection of dose levels; pathology and toxicity observations; and statistical interpretation of tumor data.
In 1992 1997, 3440 individuals were screened for thyroid pathology and their thyroid doses estimated (median, 97 mGy; mean, 174 mGy).
