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However, the selection of less drastic fixatives, and the improvement and standardization of processing procedures, may preserve nucleic acids, and possibly proteins in order to integrate new techniques to routine surgical pathology determinations.
While the error rate of manual pathology determinations is generally accepted to be in 1-5% range, inclusion of confounding cancer mimickers raises the rate to as high as 7.5% [ 53].
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Our results showed a direct correlation for both ex vivo specimen imaging and postresection neck imaging with respect to IOPTH results and the final pathology determination.
Moreover, even when a specific gene is identified to make a substantial contribution to pathology, that determination does not easily lead to an effective avenue for treatment because of the complex consequences propagated down transcriptional, translational and posttranslational circuits (7, 9).
The distribution of effects across effect types revealed that nonneoplastic pathologies dominate determination of systemic NOAEL/LOAEL, demonstrating the potential importance of this class of effects or end points to chemical regulation.
Fig. 6 Dual-spectral fluorescence molecular pathology allows simultaneous determination of HER2 and CAIX expression status.
In diagnostic pathology the accurate determination of cell counts is of substantial importance as histological cut-offs are increasingly used as a basis for determining a patient's individual therapy strategy.
The variability of Ki-67 LI determination across pathology labs is now a major concern, especially if a precise cutoff is proposed to discriminate DIN patients who should undergo RT.
Separate groups of animals were used for determination of lung pathology.
Neurologic complications were rare in our series and may have been underestimated because of the difficulty in performing brain imaging procedures and the absence of systematic post mortem determination of intracranial pathology.
8 10 An additional advantage of 3D imaging is that it allows for determination of areas of pathology which can then be chosen to be imaged at higher resolution.
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