When I look for those things that give my patient's life meaning, if I are able to understand their pathology in context of the rest of their life, and see how the ailments impact their ability to find and keep access to a balanced and centered place, and then help them to get better, I am aiming my medical approaches in exactly the right direction.
There is widespread recognition that reactive oxygen species (ROS) play key roles in normal brain function and pathology in the context of neurological disease.
Assessing the potential for a chemical to cause harm to humans must include the examination of the entire pathology database in context of the study design, the mode of action of the chemical of concern, and using the most current interpretation of a lesion to determine the significance for human health effects of a particular tissue response.
To our knowledge C4BP has not been used to treat or prevent pathology in the context of cardiovascular disease, whereas supra-normal levels of C4BP may provide a relatively safe approach.
Importantly, sex hormones most likely contribute to SS pathology in the context of genetic predisposition and environmental triggers like infections.
Further investigation is thus critical for uncovering the exact molecular mechanism underlying GRN haploinsufficiency and subsequent TDP-43 pathology in the context of FTLD.
The analyzed topics included in the present special issue allow a better mechanistic understanding of NAFLD pathology in the context of the MetSyn and further contribute to the possible implementation of important countermeasures, either preventive or therapeutic, against the disease.
The discovery of genetic mutations in CD33 and TREM2 associated with the risk of developing Alzheimer's disease (AD) [ 1– 4] has heightened the interest in defining microglia physiology and pathology in the context of disease.
Using depleting antibodies against either the CD4 antigen (depletion of Th) or the CD8 antigen (depletion of CTL), it was shown that both cell types contribute to aggravation of the pathology in the context of mdx mice [ 60].
It should be clearly understood that these charts are not normal ranges designed for the assessment of live infants, but rather to provide a range of centiles for which specific organs can be compared to previous cases without significant pathology in the context of infant autopsy.
