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In order to further investigate any identifiable CNS pathology affecting the brain, active or otherwise, we have performed PET (glucose and ammonium) and MRI scans on 7 post Kawasaki disease patients with severe behavioural difficulties (Table 4).
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It is widely believed that rodent EAE rarely affects the brain and is mostly limited to pathology of the spinal cord.
FUS pathology in aFTLD-U and BIBD is topographically heterogeneous, but largely affects the brain regions linked to symptomatology, suggesting that the clinical phenotype in these diseases is dictated in part by differential spread of FUS pathology.
Although any organ can be affected, the brain, skin, kidney, lung and heart are principal sites of pathology (6).
These approaches have been suggested also for diseases which affect the brain more globally, based on evidence for a region with relatively spared pathology [4, 7].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com