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Staining was evaluated by a pathologist; evaluation of reactivity involved a combination of the following: cellular localization of staining, staining intensity, subcellular localization, and percentage of cells staining in the primary component of the tissue type of interest.
Slides previously reviewed [ 10] were blindly re-diagnosed more than one year later by the same pathologist (evaluation of intraobserver agreement) and independently by another pathologist (evaluation of interobserver agreement).
For assays with low variation in normal and predictable direction of effect, pathologist evaluation of percentage tumor remains useful in determining the likelihood of normal contamination bias or in identifying bounds on correction rates, but less labor intensive sampling strategies may be possible to minimize the cost of these assays.
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Conclusions: Although children with RRP do not perceive their voice quality to have a negative impact on V-RQOL, speech-language pathologist evaluations and acoustic measurements show objective differences between the voices of children with quiescent RRP and those of normal, healthy controls.
These methods will be validated by comparing the results obtained from several manual (pathologist) evaluations.
Correlation between the pathologists' evaluations and between final preservation injury degree and cold ischemia time was determined using the "index of correlation rho " (Spearman's test).
Cohen's Kappa test was used to measure agreement between two pathologists' evaluations on wound healing status of resected cecal stumps.
The Gleason score is measured on a scale from 2 to 10, and it is based on a pathologist's evaluation of the patterns of two prominent cell types seen under the microscope.
Fifty articles were selected and included under the following five topics: (1) normalcy of the larynx and voice; (2) the clinical speech-language pathologist's evaluation; (3) the patient's perspective; (4) the core of vocal rehabilitation; and (5) behavioral versus organic dysphonias.
Tumor numbers were obtained by visual inspection of tissues in mice euthanized 21 days post-transplantation, and micrometastases were counted by pathologist's evaluation after dissection of the lung [7], [21], [56].
This pathologist's evaluation was used to confirm the previous diagnosis of cpAC.
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