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The PCA-ICA process provides the highest separation between the different pathologies with very similar standard deviation, achieving a high degree of accuracy with the pathologist decision.
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Of course, like any other semiautomatic method it may support the pathologist's decision.
Assessment of receptor status and S-phase fraction was, to a large extent, dependent on the size of the tumour, but evaluation of the tumour grade was mostly dependent on the pathologist's decision.
Machine learning techniques can be used in diagnosis of breast cancer to help pathologists and physicians for decision making process.
Whatever the approach, the role played by the pathologist in the clinical decision-making process has never been so central.
In cases of disagreement, the slides were evaluated by two pathologists and a final decision was made.
The mesodissection software allows a user (such as a pathologist) to make AOI decisions using an optical image, then annotate these AOIs on a digital image.
In this sense, the cobas KRAS mutation kit allows the detection of codon 61 mutations, and these can be reported distinctively from codon 12/13 mutations if required, enabling the pathologist to make informed decisions based on the available and emerging clinical evidence, as well as local practice or guidelines.
The stained slides were independently assessed by two pathologists, and any differences in decision outcomes were resolved by consensus.
The inter-observer disagreements (kappa statistics: 0.91) were reviewed a second time, followed by a conclusive decision by both pathologists.
Although we were able to control for numerous potential confounders, we could not control for the surgeon's and pathologist's experience or treatment decisions.
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