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siRNAs are very potent drug molecules, able to silence genes involved in pathologies development.
Palikaras, K., Daskalaki, I., Markaki, M. & Tavernarakis, N. Mitophagy and age-related pathologies: Development of new therapeutics by targeting mitochondrial turnover.
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The increase in nuclear copper is accompanied by marked enlargement of the nuclei and enhanced DNA synthesis, with these changes occurring before pathology development.
Furthermore, certain physiological and neuroendocrine characteristics of a personality are strong indicators for pathology development, both in experimental animals and humans.
Considering the lack of effective treatments for AD due to its multi-factorial pathology, development of novel multi-target-directed drugs are desirable.
Observation made in 8-months-old MPSIIIB and doubly mutant mice suggest that the situation may be different at later stage of the disease, when additional stimuli of innate immunity subsequent to pathology development are likely predominant.
The metabolic syndrome significantly alters the cardiac gene expression profile, with implications in cardiac pathology development [ 42].
Though stress-induced cytokine production is adaptive at the first stage, later it becomes an important link to pathology development.
Beclin-1 and MAP1LC3-B are two autophagy-related genes whose overexpression might counteract pathology development in 3 m.o.o
The second approach is based on analysis of miRNA, whose expression level changes due to a pathology development.
It is likely that similar structures are formed in neuronal and glial cells at the early stages of pathology development.
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