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"Apocalypto" is a pathological work of art.
With an alarmingly increase in pathological work, there is unfortunately, lack of well-defined standard pre-analytical processes protocols which limit the use of preserved fixed human tissue specimens for DNA analysis particularly when high amounts of DNA are needed.
Simultaneously with an alarmingly increase in pathological work, and a lack of well-defined standard pre-analytical processes protocols, the issues of tissue contamination, sample mix up/interchanging, absence of correct tissue part, and the presence of extraneous tissue in paraffin blocks have got well recognition in pathology departments.
The sentinel lymph node biopsy (SNB) procedure and pathological work up of SLN has been recently reported [ 4, 13].
Postoperative care is essential for the outcome of the patients and should include specialised anesthesiological surveillance and medical oncology advice after pathological work up of the resected metastases.
Owing to its poor prognosis, a great deal of clinical and pathological work has been undertaken to study prognostic markers in ENKTL.
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Ongoing, prospective analysis of BAP1 protein expression, assessed in all UMs during routine pathological work-up, together with other clinicopathological and genetic features is therefore necessary.
Polyarteritis nodosa may share numerous clinical symptoms with MCs; thus, patients with suspected HCV-associated polyarteritis nodosa should be correctly classified by means of wide clinico-serological and pathological work-up.
Moreover, our finding that lack of BAP1 protein can identify a subgroup of 'atypical' poor prognosis D3 patients warrants the introduction of this test into the routine pathological work-up of all UM specimens.
Thus, the DLPFC may play a key role in pathological working memory-related cognitive restraint of appetite in those with eating disorders.
Written, informed consent was obtained from the deceased's next of kin for scientific post-mortem clinico-pathological work-up and publication of the anonymized data.
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