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System-level understanding of native biological and pathological systems is needed to provide potential therapeutic targets.
Pathological systems' metabolism, cell morphology, and microenvironment have peculiar characteristics [ 207].
Research over the past two decades, however, has implicated H2S in a number of physiological and pathological systems.
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Similar to most pathological system, the role of miRNAs is complex.
Taken together, our study did not find an effect of systemically administered metoprolol on central pain processing structures, including the thalamus, neither in the healthy system, nor in the pathological system of migraineurs.
Oxford classification is the first specially-designed pathological system for evaluating the prognosis of IgAN.
When considering feedback parameters for PD, therefore, one must first establish whether the different aspects of the disease represent different manifestations of a single pathological system that could be potentially represented by a single biomarker or whether these different motor manifestations have different substrates and are therefore likely to be represented by separate biomarkers.
8 Although the KRAS mutation and mismatch repair status have shown promising prognostic and predictive values, they have yet to be incorporated into either routine pathological reporting systems or TNM staging systems.
In our study, we took advantage of the new pathological classification system, Oxford system [ 14, 15] as well as Beijing system [ 16] and did analysis in whole cohort of 623 IgAN patients, then in subgroup with eGFR > =90 ml/min/1.73 m and subgroup with eGFR < 90 ml/min.
Five current pathological classification systems were applied retrospectively to assess pathologic response after neoadjuvant chemotherapy.
Pathological grading systems (Gleason score [ 28], Helpap-Grading) are filled in by pathologists.
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