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The final pathological proof diagnosis was adenoma and borderline tumour.
This may have been due to lack of pathological proof in the earlier studies.
Pathological proof of microbiopsy gave 358 (79.6%) invasive ductal and 55 invasive lobular carcinomas, with 35.5% of SBR grade III tumours (n=111).
Prostrate cancer can only be accurately differentiated from benign prostate hyperplasia (BPH) by pathological proof, usually obtained by prostatic biopsies (PB).
Methods to obtain pathological proof for mediastinal lymph node involvement were mediastinoscopy, thoracotomy, endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) or bronchoscopy with transbronchial needle aspiration (TBNA).
In our patient, as biopsy in itself could have affected the evolution and CT aspect of the tumor, the lack of pathological proof was not redhibitory.
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Radiological complete response is thus no proof for pathological complete response (pCR); therefore, resection of the initial tumor bed is still essential in the treatment of these patients [ 77, 79].
Although no longer explicitly mentioned in the latest revision of the diagnostic criteria for MS (Polman et al. 2011), pathological VEP can provide proof of lesion dissemination in space (Polman et al. 2005; McDonald et al. 2001).
In addition, definitive proof of pathological significance for PD can only be achieved by one of the following: identifying the same mutation in complete segregation in large families, identifying multiple families with even limited segregation of the same variants or functional studies of the protein harbouring the mutations showing altered function.
The analysis of a mouse model of mild, targeted OPA1 overexpression extends the types of cell death controlled by cristae remodeling beyond apoptosis, indicates a crucial role for mitochondrial ultrastructure in tissue adaptation to pathological stimuli, and offers a proof of principle for therapies aimed at ameliorating mitochondrial cristae in acute and chronic diseases.
We also demonstrated, as the in vivo proof of concept, by pathological necropsy and NIS immunohistochemistry that these were spontaneous liver metastases from the orthotopic colon xenografts.
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