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Since microbial urease is directly involved in the infection process of many pathological organisms, this work demonstrates that thiol-CysDs represent a class of new potential urease inhibitors.
For example, mammals release dopamine as part of their systemic response to infection; pathological organisms use this signal in an attempt to survive the immune response.
Specific recognition and elimination of pathological organisms or malignant cells by antibodies were proposed over a century ago by Paul Ehrlich, who is credited for conceptualizing the "magic bullet" theory of targeted therapy.
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In addition, this study opens doors to investigate CatD orthologues in pathological unicellular organisms as a target for therapeutic necrosis induction.
(3) The results of pathological micro-organisms culture are negative.
(2) The positive pathological micro-organisms culture and (or) chronic inflammatory changes in bone biopsy.
These findings suggest that the desensitization of the response to agonist in cell of hypothyroid rats is dependent on PKC down regulation at such pathological state of organism.
In the adult organism, pathological conditions such as injury, inflammation, or aging can awaken EndMT and induce the fibrosis of the involved organs.
DNA double-strand breaks (DSBs) are associated with different physiological and pathological processes in different organisms.
Hypoxia, or low oxygen availability, is an important physiological and pathological stimulus for multicellular organisms.
Understanding the spatial context in which molecular interactions take place is becoming increasingly important in the study of biological and pathological processes in living organisms.
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