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On the pathological observations, marked accumulation of lipid was observed in the mice infected with P. gingivalis.
Here we perform a comprehensive behavioral characterization of this model, discuss how the observed behavior correlates with the mechanistic and pathological observations of others, and compare this model with other commonly used AD mouse models.
In tissue biomarker studies, the heterogeneity of disease tissues and pathological observations are often not considered, and tissues are homogenized as a whole for protein extraction.
Deposits of amyloid β (Aβ) plaque are one of the pathological observations in patients with Alzheimer's disease (AD); Aβ deposition progresses at an earlier point than the current clinical diagnostic point for this disease [1].
This guideline explains that unblinded evaluation is regarded as the appropriate approach in the first round of pathological observations because it 'allows the pathologist to intensely focus the histopathologic evaluation and to find important, and sometimes subtle, differences between the tissues of treated and untreated animals'.
Summarizing previous reports and adding his own clinical and pathological observations, Charcot called the disease sclerose en plaques.
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Non-specific death is often observed in the course of experiments, so pathological observation can precisely provide the most important criterion for evaluating the efficacy of plague vaccines.
Further, sporadic eosinophilic changes and nuclear pyknosis were visible in hepatic pathological observation.
The thrombus was yellow (Fig. 4a), and pathological observation showed that it consisted of fibrous material including many neutrophils and macrophages.
Based on the results of this pathological observation, we made the hypothesis about classification and summarized the pathogenic factors of PVG-causing IP into (1) infection, (2) mucosal rupture + increased intraluminal pressure, and (3) mixed type (Table 1).
This finding is also in agreement with the pathological observation in the case of orally administrated zinc oxide nanoparticle to mice [29], where both oral and intra-peritoneal administration of the nanoparticle at different doses demonstrated inflammatory changes in the liver, kidney and lungs [29].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com